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KMID : 0861120110150020069
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Korean Journal of Oriental Preventive Medicine
2011 Volume.15 No. 2 p.69 ~ p.99
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Review of Pharmacological Effects of Scutellaria Baicalensis and Its Bioactive Co
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Lee Geon-Seok
Park Min-Hee
Cheon Mog-Eun
Hong Jin-Woo
Cho Su-In
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Abstract
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Objective : Scutellaria baicalensis is one of the most popular and multi-purpose herb in traditional medicine. It is also useful for its practicability to cultivate in Korea. The purpose of this study is to contribute to researches and applications of scutellaria baicalensis by analyzing and reviewing international researches on the compositions and the effects of scutellaria baicalensis.
Methods : This study analyzed 146 articles from PubMed by searching with the keyword "Scutellaria baicalensis", "Huang quin", "Baical Skullcap", "Huang qin", "baical skullcap root", "ogon", "Hwanggeum" and "Hwangkeum", published within the last 10 years(from 2000 to 2009). We reviewed the 146 articles on Scutellaria baicalensis and its active constituents in terms of ’Active constituents’, ’Experimental studies’, ’Clinical studies’, ’Drug interaction’, ’Side Effects/Toxicity’ and ’Pharmacokinetics’.
Results : The active constituents of Scutellaria baicalensis are flavonoids such as baicalein, baicalin, wogonin and oroxylin-A. It is reported that scutellaria baicalensis and its active compounds have antiinflammatory activity, antitumor activity, antioxidant activity, antiviral and antibiotic activity, neuroprotective effects, hepatoprotective effects and cardiovascular effect.
Conclusions : This study is aimed to summarize the results obtained within the last 10 years and to contribute to following researches and applications of Scutellaria baicalensis.
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KEYWORD
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Scutellaria baicalensis, Baicalein, Baicalin, Wogonin, Wogonoside, Oroxylin-A
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